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Breast Cancer  Support –

Beyond BRCA: Links between breast, second primary cancer and inherited mutations

Rates of inherited mutations in genes other than BRCA1/2 are twice as high in breast cancer patients who have had a second primary cancer — including, in some cases, different types of breast cancer — compared to patients who have only had a single breast cancer. But the rates of these mutations were still found to be low overall, meaning it’s difficult to assess whether and how these individual mutations may drive the development of cancer.