Tamoxifen Side Effects Explained As 6 In 7 Women Say They Don’T Use Drug For Breast Cancer Prevention
Researchers said there were three main factors for why they avoided the drug: fear of side effects, distrust of medication in general and believing cancer was down to fate.
Previous research found those at increased risk of the disease had a reduced risk of around a third after taking the drug, which led to its approval for prevention. But what else do we know about it?
A new study funded by Cancer Research UK and published in Breast Cancer Research and Treatment asked 258 healthy but ‘at risk’ women across England whether they had agreed to take the drug to help prevent breast cancer developing. Researchers also interviewed 16 women to identify what influenced their decision to take it.
They found just one in seven women had agreed to take it as a preventative measure, with mothers being more likely to take up the offer.
What is tamoxifen?Tamoxifen is a hormonal therapy drug used to treat breast cancer. It’s most commonly given to women who have been treated for breast cancer to lower the risk of it coming back. But in 2013 the National Institute for Health and Care Excellence (NICE) also approved it for cancer prevention in premenopausal women at increased risk of the disease due to a family history of breast or ovarian cancer.
The drug, which is usually taken daily in tablet form for five years, works by stopping the female hormone oestrogen from encouraging breast cancers to grow.
Women can access the drug through a family history clinic or a genetics clinic, following a referral from their doctor. (If you’re concerned about your risk, speak to your GP.) Melanie Sturtevant, policy manager at Breast Cancer Now says it is “unclear” whether these conversations are always happening in the clinic and that “many GPs lack confidence in discussing the option, with many others not even being aware of it”.
Like many types of medication, it does have its downsides. Sturtevant says the drug “can have some really difficult side-effects for women, most commonly menopausal symptoms such as hot flushes and sleep disturbance”, which can make the decision to take them quite hard.
Other possible side effects include: vaginal discharge, itching or dryness; irregular, lighter or non-existent periods; reduced sex drive; nausea and indigestion; eye problems; effects on the nervous system (for example pins and needles or tingling in the arms and legs, dizziness or taste changes); leg cramps; muscle pain; tiredness; lack of energy; skin rashes; hair thinning; weight gain; and changes in mood and concentration.